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KMID : 0351619690100010177
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Kyungpook Medical Journal
1969 Volume.10 No. 1 p.177 ~ p.182
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The Effects of Ethionine on Protein Synthesis of Regenerating Liver in Rats
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Abstract
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The effect of the administration of ethionine upon protein synthesis in the liver of male and female rat after partial hepatectomy was investigated by measuring the incorporation of L-lysine-C14 into total liver and plasma protein in *ira.
Ethionine administration inhibited the synthy is of liver and plasma protein more significantly in female rats before partial hepatectom-r. At 20 hrs. post-hepatectomy(excised about +´1% of total liver weight), the sex difference in ethionine inhibition still exsisted, but at 36 and YO hrs. , when the liver protein synthesis was -acct active.,, no more the difference was obse-reve
When the rats were fed with 1% DL-ethioninediet and normal diet alternately at interval of 5-? days, severe weight loss on ethionine diet and quick recovery on normal diet were observed in both sexes. On the 5th day on normal diet after the ethionine pretreatment for one month, the rats of both sexes were partially hepatectomized and studied hepatic protein synthesis and histological changes with following results 1) no sex difference was observed in liver and plasma protein synthesis, and 2) histologically, remarkable fatty change was noted in regenerating liver (401irs. post-hepatectomy) of female rats where no noticeable induction of fatty liver by ethionine was seen at operation. In male rats, fatty liver was not observed even in regenerating liver.
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KEYWORD
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